Nitroglycerin OintmentRx

Trade Names: Nitro-Bid Ointment

Synonyms: Nitropaste, NTG, glyceryl trinitrate

Drug Class: Nitro vasodilator 1-, 30-, 60 g

Preparations: 2% ointment

Dose: For angina, 1/2 inch twice daily initially, increased to 1 inch twice daily if needed with a 12 hour nitrate free interval.  For digital ulcers, smaller amounts are applied to the fingertips.

Indications: Angina, severe Raynaud’s syndrome with digital ulceration

Mechanism of Action: Nitric oxide donor. Nitric oxide acts through cyclic guanosine monophosphate to relax vascular smooth muscle.

Contraindications: Hypersensitivity to nitroglycerin, concommitant use of sildenafil (Viagra) or other phosphodiesterase-5 inhibitors

Pregnancy Risk: C

Adverse Effects
Common: Flushing, headache, dizziness, rash

Comments:  Small amounts on tips of fingers tried for digital ulcers. Efficacy is uncertain.

Clinical Pharmacology: Systemic absorption occurs transdermally, and this preparation is used to treat angina. Duration of action is 10–12 hours.

Cost: $